Efficient Reductive Amination Using Hantzsch 1,4-Dihydropyrindine as Organo Reducing Agent in the Presence of Sc(OTf)3 and Acidic Silica at Ambient Temperature

Abstract

Reductive amination of carbonyl compounds stands out as a potent method in the synthesis of structurally diverse amines. The synthesis of amine is an important reaction in drug discovery as well as in synthetic organic chemistry. It can lead to the synthesis of a variety of natural products as well as highly biologically active molecules. Present protocol deals with the reductive amination of aldehydes with aryl amines using Scandium triflate [Sc(OTf)₃]-acidic silica as a catalyst and Hantzsch-1,4-dihydropyridine (HDHP) as an organo reducing agent in toluene solvent at ambient temperature. Notably, the reaction demonstrates a high degree of selectivity, resulting in very good yields.