Study of Antimicrobial Activity in Bioactive Heterocyclic Compounds

Abstract

Antimicrobial resistance poses a significant global health threat, necessitating the continuous search for novel antimicrobial agents. Heterocyclic compounds have emerged as promising candidates due to their diverse structural properties and bioactivity. This study investigates the antimicrobial activity of a series of bioactive heterocyclic compounds against a panel of pathogenic microorganisms.A library of heterocyclic compounds was synthesized using well-established organic synthesis techniques and characterized by spectroscopic methods. The compounds included various nitrogen, oxygen, and sulfur-containing heterocycles, each designed with specific structural features to target microbial pathogens. Minimum inhibitory concentration (MIC) assays were performed to assess the antimicrobial potency of these compounds against a range of Gram-positive and Gram-negative bacteria as well as fungal strains.Our results demonstrate that several of the synthesized heterocyclic compounds exhibit potent antimicrobial activity, with MIC values in the low microgram to milligram per milliliter range